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KMID : 0370220110550040314
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Yakhak Hoeji
2011 Volume.55 No. 4 p.314 ~ p.318
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Neuroprotective Effect of the Aerial Parts of Taraxacum officinale on Glutamate-induced Oxidative Injury in Mouse Hippocampal HT22 Cells
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Li Bin
Lee Dong-Sung
Choi Hyun-Gyu
Kim Kyoung-Su
Ji Hye-Young
Rho Jung-Mi
Kim Ki- Mo
Kim Youn-Chul
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Abstract
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Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. In the present study, we investigated the neuroprotective effects of the standard extracts of Taraxacum officinale Weber, one of the original plants of Taraxaci Herba, on glutamate-induced oxidative injury in mouse hippocampal HT22 cells. The standard EtOH extract of the aerial parts of T. officinale (NNMBS270) showed significant cytoprotective effects on glutamate-induced neurotoxicity and induced the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells, while the roots’ extract (NNMBS271) did not show neuroprotective effect. These results suggest that the extract of the aerial parts of T. officinale could be an effective candidate for the treatment of ROS-related neurological diseases.
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KEYWORD
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glutamate-induced toxicity, Taraxaci Herba, Taraxacum officinale, HT22, heme oxygenase-1, neuroprotective effect
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